THE ANTIOXIDANT FOR LONGEVITY & CELLULAR DEFENSE
Trans-Resveratrol
Trans-Resveratrol is a powerful polyphenol found in red grapes, berries, and Japanese knotweed—best known for its role in promoting cellular health and longevity. It acts as a potent antioxidant, helping to neutralize free radicals and reduce oxidative stress, one of the key drivers of aging. Trans-Resveratrol has also been shown to activate sirtuins, a group of proteins linked to DNA repair, inflammation control, and healthy aging. With its ability to support cardiovascular health, cognitive function, and cellular resilience, it’s a core ingredient in modern longevity science.
Real-Life Issues Trans-Resveratrol Can Tackle
Backed by Science
At NATURIQ, we don’t just believe in our ingredients—we back them with science. Every formula we create is rooted in evidence, not trends. Trans-Resveratrol is a well-researched antioxidant known for its ability to reduce oxidative stress, support cardiovascular health, and activate sirtuins—proteins linked to DNA repair and longevity.
In this section, you'll find a selection of clinical studies and scientific publications that explain how and why Trans-Resveratrol protects cells, supports brain and heart health, and contributes to healthy aging—so you can feel confident in what you’re putting into your body, and why it matters.
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Title: Resveratrol improves mitochondrial function and protects against metabolic disease
Authors: Baur JA, Pearson KJ, et al.
Published in: Nature, 2006
Summary: This landmark study found that resveratrol improves mitochondrial function and insulin sensitivity, mimicking some effects of caloric restriction. It supports resveratrol's potential in extending healthspan and improving metabolic health. -
Title: Resveratrol as a calorie restriction mimetic: therapeutic implications
Authors: Barger JL, Kayo T, Vann JM, et al.
Published in: Trends in Endocrinology & Metabolism, 2008
Summary: Shows that resveratrol activates SIRT1 and other longevity genes similar to calorie restriction, suggesting benefits for aging, inflammation, and age-related disease prevention. -
Title: A double-blind, placebo-controlled study of resveratrol on cognition and cerebral blood flow
Authors: Witte AV, Kerti L, Margulies DS, Flöel A
Published in: Journal of Neuroscience, 2014
Summary: Demonstrated that resveratrol supplementation improves memory performance and increases functional connectivity in the brain, suggesting potential cognitive and neuroprotective benefits.
WHY WE USE TRANS-RESVERATROL AT NATURIQ
“We use Trans-Resveratrol because it helps protect your cells and extend their vitality. Known as the “longevity molecule,” it works deep within the body to reduce oxidative stress, support heart and brain health, and activate key longevity pathways like sirtuins. Backed by decades of research, it’s one of the most trusted antioxidants in modern wellness—and a cornerstone of our approach to graceful aging and long-term resilience.”
READY TO LIVE TO 100?
Renew
Renew is our science-backed supplement, made in Germany, to support energy, focus, and healthy aging—so you can feel your best at every age.
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Crafted to the highest standards with premium ingredients and strict quality control, because your body deserves nothing less.
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Every capsule is packed with longevity-focused nutrients—like NMN, trans-resveratrol, quercetin, designed to support energy, cellular repair, and graceful aging.
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Backed by science for improved energy, cognitive clarity, and healthy aging—one capsule at a time.
What is Trans-Resveratrol?
Trans-Resveratrol is the most active and bioavailable form of resveratrol, a natural polyphenol found in foods like red grapes, berries, peanuts, and particularly in the skin of red wine grapes. Recognized for its powerful antioxidant and anti-aging properties, Trans-Resveratrol has become one of the most studied compounds in the field of cellular health and longevity. It plays a central role in protecting cells from oxidative damage, reducing inflammation, and promoting the body’s natural repair processes.
One of the key mechanisms behind Trans-Resveratrol’s benefits is its ability to activate sirtuins—especially SIRT1. Sirtuins are a group of proteins that regulate important biological functions such as DNA repair, inflammation control, and cellular aging. Activating these proteins mimics the effects of caloric restriction, a well-documented method for extending lifespan and improving metabolic health in various organisms. Because of this, Trans-Resveratrol is often referred to as a “longevity molecule.”
In addition to activating sirtuins, Trans-Resveratrol is a potent antioxidant that helps neutralize free radicals—unstable molecules that cause oxidative stress and cellular damage. Oxidative stress is a major contributor to aging and is linked to chronic conditions such as cardiovascular disease, neurodegenerative disorders, and insulin resistance. By reducing oxidative stress, Trans-Resveratrol helps preserve mitochondrial function, supports energy production, and promotes healthy aging at the cellular level.Trans-Resveratrol is also widely recognized for its cardiovascular benefits. It has been shown to support healthy blood circulation, improve endothelial function (the health of blood vessel linings), and reduce the oxidation of LDL cholesterol, which is a key factor in the development of plaque in the arteries. These effects contribute to better heart health and may help reduce the risk of age-related cardiovascular issues.
Brain health is another area where Trans-Resveratrol shows promise. Research suggests it may enhance memory, improve focus, and protect against cognitive decline by increasing cerebral blood flow and reducing inflammation in neural tissues. These neuroprotective benefits make it a popular supplement for those looking to maintain mental sharpness as they age. Because it’s the trans-isomer, Trans-Resveratrol is more stable and effective than its counterpart, cis-resveratrol, which is less bioactive and breaks down more easily. However, like many polyphenols, Trans-Resveratrol naturally has low bioavailability. To address this, high-quality supplements often use advanced delivery systems such as liposomal or phytosomal encapsulation, or they pair it with ingredients like piperine to improve absorption.
Trans-Resveratrol is generally well tolerated when used as directed. It is commonly included in anti-aging supplement routines alongside other cellular health nutrients like NMN and CoQ10, where it helps support mitochondrial function and overall vitality. In summary, Trans-Resveratrol is a powerful compound that supports cellular defense, cardiovascular function, cognitive performance, and healthy aging. By working at the molecular level to activate longevity pathways and protect against oxidative stress, it provides comprehensive support for long-term energy, resilience, and wellness.
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